US20110165626A1 – High Yield Production of Sialic Acid (Neu5ac) by Fermentation – Google Patents

Different AAV serotypes display distinct tissue tropism, believed to be related to the distribution of their receptors on target cells. The AAV serotype helper plasmids pXR1, pXR2, pXR4, and pXR5,…

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Terminal Sialic Acids are an Important Determinant of Pulmonary Endothelial Barrier Integrity

This was followed by the addition of neuraminidase solution or buffer control to each well and continued resistance measurement 4 (or more) h. More specifically, following treatment with neuraminidase from…

Continue ReadingTerminal Sialic Acids are an Important Determinant of Pulmonary Endothelial Barrier Integrity

US20110165626A1 – High Yield Production of Sialic Acid (Neu5ac) by Fermentation – Google Patents

"Commercial scale" refers to gram scale production of a sialic acid in a single reaction. In preferred embodiments, commercial scale refers to production of greater than about 50, 75, 80,…

Continue ReadingUS20110165626A1 – High Yield Production of Sialic Acid (Neu5ac) by Fermentation – Google Patents

US20110165626A1 – High Yield Production of Sialic Acid (Neu5ac) by Fermentation – Google Patents

This observation was further supported by the staining with fluorescently tagged lectin from Arachis hypogaea following neuraminidase treatment. TRITC-tagged lectin from Arachis hypogaea did not bind to treated cells (B),…

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